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As a resource for those working in the microencapsulation field the following is a database of review articles including author details and full abstracts.


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Recent Additions

2011 - Microencapsulation of Ginger Oil in 18DE Maltodextrin/Whey Protein Isolate

Alhassane Tour; Hong Bo Lub; Xiaoming Zhang; Xu Xueming  - Journal of Herbs, Spices & Medicinal Plants Volume 17, Issue 2, 2011, Pages 183 - 195

Essential oil from fresh ginger was extracted by steam distillation. Microencapsulation of volatile ginger oil was done by spray-drying using maltodextrin and whey protein isolate as wall materials. An orthogonal design was used to evaluate the influence of the capsule wall materials on the oil retention (OR) and microencapsulation efficiency (MEE) of ginger oil by spray-drying. The best conditions for higher MEE and OR were found to be a 1:1 ratio of whey protein isolate to maltodextrin, a 1:4 ratio of core to wall material, and total solid content of 25%. The spray-drying conditions used were homogenizer pressure at 30 MPa, inlet air temperature at 120°C, and outlet air temperature of 60°C. MEE and OR were 99.36% and 93.30%, respectively. Scanning electron microscopy showed that the microcapsules were free of visible cracks and pores. Gas chromatography coupled with mass spectrometry showed only slight loss during spray-drying.
2011 - A new oral vaccine candidate based on the microencapsulation by spray-drying of inactivated Vibrio cholerae

Gemma Año, Amaia Esquisabel, c, Marta Pastor, c, Arturo Talaver, Bárbara Cedré, Sonsire Fernández, Sergio Sifontes, Yisabel Aranguren, Gustavo Falero, Luis García, Rosa Lydia Solís and José Luis Pedraz, Vaccine Article in Press online @ http://www.sciencedirect.com/science/article/pii/S0264410X11008644

The aim of this work was to evaluate the microencapsulation by spray-drying of inactivated Vibrio cholerae, using methacrylic copolymers Eudragit® L30D-55 and FS30D. The microparticles obtained presented a particle size around 3.0 μm. The preparation temperature affected the morphology and the antigenicity of microparticles, but it did not affect the V. cholerae content. In vitro release studies showed that in acid medium less than 5% of bacteria was released, and in neutral medium, Eudragit® L30D-55 microparticles released 86% after 24 h, whereas FS30D released less than 30%. Rats inoculated with microparticles exhibited vibriocidal antibody titres. Microencapsulation by spray-drying of inactivated V. cholerae could be proposed as a method to obtain an oral vaccine which provides controlled release of the bacteria.
2011 - Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract

IC Obidikea and MO Emeje - Journal of Ethnopharmacology Article in Press online @ http://www.sciencedirect.com/science/article/pii/S0378874111004296

The aim of the present study was to evaluate the anti-ulcer properties of Entada africana (EA) ethanol leaf extract and to obtain a novel multiparticulate pharmaceutical formulation (ACE) with it. Acute toxicity test (LD50) was also carried out in mice. The extract exhibited significant (P < 0.01) cytoprotective effect against ethanol and indomethacin induced gastro ulceration. Microcapsule dosage form with sodium alginate containing Entada africana extract was prepared. The microcapsules showed enhanced cytoprotective effect against ethanol and indomethacin induced gastro ulceration. Histopathologically, the effects of EA and ACE on mucus epithelia were mild with reduced neutrophil, eosinophil and lymphocytic infiltration in stomach tissues of rats ulcerated with ethanol. Our current findings show that EA and its multiparticulate formulation may be a useful preparation in peptic ulcer disease.


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